Brewers vs Cardinals Prediction 27 September 2026
π‘ Milwaukee enter the final game of the regular season with a 102-59 record, having already claimed back-to-back wins over St. Louis-8-4 and 3-2. The Brewers have taken eight of their last ten, while the Cardinals have dropped eight in that same stretch. On Sunday, the hostsβ advantage is further boosted by the starting pitching matchup: Jacob Misiorowski faces off against Andre Pallante. Considering recent form, head-to-head results, and the pitching duel, Milwaukee are in an excellent position to close out the series on a high note.
Milwaukee have won nine of their last ten meetings against St. Louis.
π This is one of the most pronounced head-to-head trends of the game day: Milwaukee have come out on top in nine of their last ten meetings with St. Louis. In the current series, the Brewers started with an 8-4 win and then edged a close 3-2 contest. Before that, they posted victories of 8-4, 10-2, 4-3, 4-3, 2-1, 6-0, and 5-1. St. Louisβ only success in this recent run came in a 5-1 win back in July.
Head-to-head statistics Brewers - Cardinals

The Brewers close out the season on a winning streak, showcasing Misiorowski, who posts a 1.86 ERA.
The Brewers boast the better overall record in this matchup-102-59, including an impressive 54-26 at home. Over their last 10 games, Milwaukee are 8-2 and currently riding a four-game winning streak. During this stretch, the Brewers have posted wins of 4-1, 5-1, 8-4, and 3-2, showing they can control both low-scoring battles and more open contests. On the season, they average 5.13 runs per game while allowing just 3.81.
Match Results: Milwaukee Brewers

The Cardinals have dropped eight of their last ten and are once again struggling to find their rhythm on offense.
The Cardinals are 77-84 and have dropped eight of their last ten games. Their offense has struggled mightily during this stretch: in five recent outings, they've been held to two runs or fewer on three occasions. They managed to put up four runs in Milwaukee to start the series, but their bats cooled off again on Saturday, scoring just two. If they want to clinch the series finale on the road, they'll need a much stronger offensive showing against a pitcher whoβs enjoying one of the best seasons among the leagueβs young arms.
Match Results: St. Louis Cardinals
βΎ Starting Pitchers
Jacob Misiorowski enters the game with a 15-5 record, a 1.86 ERA, and 247 strikeouts. Thatβs a massive edge on the mound. In his last head-to-head clash with St. Louis on July 7, he went seven innings as Milwaukee edged out a 4-3 win. His combination of a low ERA and high strikeout rate poses a real problem for a lineup thatβs been struggling to put up more than one or two runs per game.
Andre Pallante takes the hill with a 12-8 record and a 3.61 ERA. Heβs put together a solid season, giving St. Louis a shot to keep things close early on. However, Pallante already faced Milwaukee on July 9 and gave up enough for the Brewers to claim an 8-4 victory. Against a team averaging over five runs per game, thereβs little room for error.
β Editorial Prediction
St. Louis have landed a decent starting pitcher, but nearly all other key metrics tip the scales in favor of the hosts. Milwaukee have taken nine of the last 10 head-to-heads, eight of their previous 10 games overall, and the opening two matchups of this series. Misiorowski comes in with a stellar 1.86 ERA, giving the Brewers a clear edge on the mound against a lineup that consistently struggles to score more than three runs. Meanwhile, the Brewers are averaging 5.13 runs per game and boast a formidable 54-26 home record. Even if itβs close early on, Milwaukeeβs depth and current form make them the more reliable pick. The editorial choice: Milwaukee Brewers to win.
