Sao Paulo vs Atletico Nacional Prediction
📢 What to expect from the second leg of the Copa Libertadores Round of 16 clash between São Paulo and Atlético Nacional? Both teams are delivering solid performances in their respective leagues, but right now, their focus is firmly on securing a victory. The first leg ended in a 0-0 draw, adding an extra layer of intrigue to this upcoming showdown where everything is still up for grabs. Despite São Paulo facing some offensive challenges, their defense has been impressively reliable, which could prove to be a decisive factor in the return fixture.
Head-to-Head
The last official encounter between the teams took place on 13 August 2025 and ended with a scoreline of 0:0. Here's a comparative breakdown of that match (home team - Atletico Nacional Medellin):
- ball possession percentage: 55% vs 45%;
- corner kicks: 8 vs 3;
- fouls: 18 vs 13;
- yellow cards: 2 vs 2;
- shots on target: 1 vs 0.
📊Statistical preview of official matches between the teams Sao Paulo and Atletico Nacional Medellin:
- played 7 matches;
- number of wins for the home team - 2, for the away team - 3, draws - 2;
- number of goals - 5 against 7;
- average total in the 1st half - 0.71, in the 2nd half - 1;
- average total goals in the match - 1.71.
H2H Stats Matches and Previous Teams Results

Sao Paulo Team Overview
The team's most recent official match took place on as part of the Serie A tournament (home team - Recife PE, away team - Sao Paulo). The match concluded with a scoreline of 2:2.
Here's the game statistics (Sao Paulo vs Recife PE):
- ball possession: 67% vs 33%;
- corner kicks: 10 vs 4;
- fouls: 19 vs 17;
- yellow cards: 1 vs 4;
- shots on target: 8 vs 5.
São Paulo are showcasing consistent form. The team have won four of their last seven matches and drawn the other three, remaining unbeaten. They average 1.43 goals per game, which highlights their attacking potential even though they have struggled against Atlético Nacional, scoring no more than one goal in six consecutive head-to-head encounters. However, it's their defense that remains the team's biggest asset, conceding just 0.57 goals per game. Their playing style focuses on ball control and utilizing speedy wingers to create dangerous opportunities.
Match Results: Sao Paulo

Atletico Nacional Medellin Team Overview
The away team played their last official match on as part of the Liga Aguila tournament (home team - Atletico Nacional Medellin, away - Fortaleza C.E.I.F). The match concluded with a scoreline of 2:2.
Here are the match stats (Atletico Nacional Medellin vs Fortaleza C.E.I.F):
- ball possession: 62% vs 38%;
- corner kicks: 12 vs 3;
- fouls: 15 vs 11;
- yellow cards: 3 vs 3;
- shots on target: 7 vs 6.
Atlético Nacional are also on a strong run, going unbeaten in their last seven matches across all competitions. The "Verdolagas" display consistent performances both at home and away, averaging one goal per match. Defensively, they concede just 0.86 goals per game. Their style relies on swift counterattacks and a compact defense, making them a challenging opponent for any club.
Match Results: Atletico Nacional Medellin
Latest news
Sao Paulo
🚫 São Paulo are facing a challenging situation with their squad as several players remain unavailable. Jonathan Calleri is sidelined for an extended period due to a severe cruciate ligament injury, with his return not expected until December. Ryan Francisco has sustained a similar injury and will miss the entire season. In the coming weeks, the team will also be without Robert Arboleda and Oscar, who are recovering from a thigh injury and back issues, respectively. Additionally, Wendell is expected to recover by the end of August, while Luis Gustavo's ailment will also keep him out of upcoming matches.
📣 Head coach Hernan Crespo took a philosophical approach to the result of the first match: "A goalless draw is, you could say, a rather lenient result for us. But we are taking it in stride-it was an away game, and such a scoreline is considered normal."
Atletico Nacional Medellin
🚫 Atlético Nacional are also grappling with squad issues. Facundo Batista is sidelined for an extended period due to a foot fracture, with his return anticipated only in November. Sebastián Guzmán and Dairon Asprilla are set to miss the coming weeks as both have been diagnosed with muscle injuries. Additionally, César Haydar won't be available to support his teammates.
📣 Head coach Javier Gandolfi was left disappointed by the outcome of the first encounter, believing his team deserved more: "A draw is too modest a result for us. But we're heading to Brazil with the aim of winning and advancing to the next round." Despite this, the coach emphasized his satisfaction with the team's performance and his belief in success in the return leg: "We maintain full confidence. After these initial 90 minutes, I feel satisfied and proud, as the team showcased many positive aspects."
Prediction for the 1st half
Head-to-Head Matches:
- Total encounters - 7;
- First-half wins at home for hosts - 0; for visitors away - 0; number of draws - 3;
- Average first-half total: 0.71;
- Today's home team scores on average 0.29, while the visitors net 0.43.
First-Half Stats: Sao Paulo (home) vs Atletico Nacional Medellin (away)
- matches played in the tournament: 3 vs 3;
- wins: 1 (33.33%) vs 0 (0%);
- losses: 0 (0%) vs 0 (0%);
- draws: 2 (66.67%) vs 3 (100%);
- Average goals scored: 1.33 vs 0;
- Average goals conceded: 0.33 vs 0.
Last 10 Matches (Overall):
- wins: 5 vs 6;
- losses: 1 vs 2;
- draws: 4 vs 2;
- Average first-half total: 0.9 (scored - 0.7, conceded - 0.2) vs 1.4 (scored - 1, conceded - 0.4).
- Sao Paulo have drawn in the 1st half in 6 of last 7 games against Atletico Nacional Medellin.
Prediction on the outcome
H2H:
- number of encounters - 7;
- home team wins - 2, away team wins - 3, draws - 2.
Statistics: Sao Paulo vs Atletico Nacional Medellin
- matches played in the tournament: 6 vs 6;
- wins: 4 vs 3;
- win percentage: 57% vs 43%;
- losses: 0 vs 3;
- draws: 3 vs 1.
Last 10 matches:
- wins: 6 vs 5;
- losses: 1 vs 1;
- draws: 3 vs 4.
- Atletico Nacional Medellin won with a +1.5 handicap in last 7 games against Sao Paulo.
- Atletico Nacional Medellin won with a +1.5 handicap in last 28 games.
- Atletico Nacional Medellin won with a +1.5 handicap in last 12 away games.
- Atletico Nacional Medellin won with a +1.5 handicap in last 5 games (Copa Libertadores).
Prediction on the over/under
H2H
- today's home team scores on average - 0.71, the guests - 1;
- average Over/Under goals in H2H matches - 1.71;
- both teams scored: overall - 2; at the home team's field - 1.
Statistics: Sao Paulo vs Atletico Nacional Medellin
- average total in the tournament: 2 vs 1.86;
- average total goals scored: 1.43 vs 1;
- average total in the 1st half: 0.57 vs 0.29;
- average total in the 2nd half: 0.86 vs 0.71;
- Sao Paulo: average total at home in the tournament - 1.67;
- Atletico Nacional Medellin: average total away in the tournament - 0;
- last 10 matches (average total): 1.6 (home - 2.25) vs 1.7 (away - 1.75).
- Sao Paulo have scored under 1.5 goals in last 6 games against Atletico Nacional Medellin.
Prediction on corners
Sao Paulo: Statistics
- season: average Over/Under in the tournament - 3.71; at home field - 4.67;
- last 10 matches: average Over/Under - 5.2; at home field - 5.
Atletico Nacional Medellin: Statistics
- season: average Over/Under in the tournament - 5.29, away - 4.33;
- last 10 matches: average Over/Under - 6.3; away - 5.
Prediction on cards
H2H
- average Over/Under yellow cards in H2H matches - 4.86 (2.43 for home team and 2.43 for away team);
- average Over/Under yellow cards at the home team's field - 3.66 (1.33 for home team and 2.33 for away team).
Sao Paulo: Statistics
- season: average Over/Under in the tournament - 2.29; at home - 2;
- last 10 matches: average Over/Under - 2.1; at home - 2.75.
Atletico Nacional Medellin: Statistics
- season: average Over/Under in the tournament - 2.14, away - 1.67;
- last 10 matches: average Over/Under - 2.6; away - 3.
Prediction on BTTS
H2H:
- number of encounters - 7;
- both teams scored all-time - 2 times;
- on the home team’s field - 1 times.
Statistics: Sao Paulo vs Atletico Nacional Medellin
- number of matches played in the tournament: 6 vs 6;
- number of matches in the season where both teams scored (BTTS): 3 vs 1;
- number of BTTS matches for Sao Paulo at home - 3 (100%);
- number of BTTS matches for Atletico Nacional Medellin away - 0 (0%).
Last 10 matches:
- number of BTTS matches: 5 vs 5;
- BTTS matches for Sao Paulo at home - 2 (50%);
- BTTS matches for Atletico Nacional Medellin away - 2 (50%).
Editorial Prediction
São Paulo are considered the favorites in the upcoming clash and will aim to leverage their home advantage to advance further. However, Atlético Nacional are in excellent form right now; they looked significantly sharper in the first leg, and it was only by a stroke of luck that the Brazilians managed to hold onto a draw. It's also worth noting the head-to-head trend-São Paulo have not scored more than one goal in their last six encounters against this Colombian side. Given these circumstances, betting on São Paulo's total under 1.5 goals seems like a reasonable call.