Reds vs Cubs Prediction 18 September 2026
📡 Cincinnati have just spoiled the Dodgers’ bid to clinch the series and now face another top National League contender. The Cubs arrive with an 85-68 record, while the Reds stand at 71-82. Great American Ball Park is known for high-scoring affairs, but today’s starters-Chase Burns and Clay Holmes-take the mound with ERAs of 2.80 and 2.85, respectively. With the total set at 10.5, there’s a significant margin for the pitchers to work with.
Chicago and Cincinnati have already turned this matchup into a shootout on more than one occasion.
📊 Head-to-head statistics serve as the main argument against opting for a low-scoring choice. The Cubs have won seven of their last 10 games, with six of those matchups going over the total: the August series alone featured scores of 7-5, 17-5, and 10-8. However, July and May offered a different story with games ending 5-3, 4-0, 3-2, and 5-4. Thus, the H2H data suggests high variability rather than a guaranteed shootout.
Head-to-head statistics Reds - Cubs

The Reds turn to Burns to address their usual starting pitching woes.
The Reds are averaging 4.14 runs per game, but they're conceding over five-a risky combination for any under, especially at home. However, today’s starter, Burnes, gives the team a chance to address the weakest link in their formula: early pitching. Cincinnati have just wrapped up a four-game set against the Dodgers, with the first three matchups producing five, four, and eight total runs.
Match Results: Cincinnati Reds

The Cubs are dangerous going forward, but Holmes sets a more composed tempo for the game.
Chicago remain one of the league’s most productive lineups, averaging 5.34 runs per game. However, the Cubs arrive after a series against Atlanta where two of three games were defined by strong starting pitching. The biggest threat to the total here is Chicago’s ability to punish Cincinnati’s shaky bullpen, which holds a 4.75 ERA according to Covers. Until that point, Burns will need to give the hosts a chance to keep the score within reach.
Match Results: Chicago Cubs
⚾ Starting Pitchers
Chase Burns is enjoying an outstanding season, going 15-3 with a 2.80 ERA and 181 strikeouts. Over his last five starts, he’s posted a 4.87 ERA-though that number is skewed by one rough outing. On August 30 against the Cubs, Burns worked 5.2 innings, surrendering three runs (two earned). His knack for racking up strikeouts is a major asset against Chicago’s potent lineup.
Clay Holmes takes the mound with a 6-7 record and a 2.85 ERA. In his last five outings, he’s posted a 3.49 ERA, allowing no more than one earned run in three of those games. Holmes doesn’t always go deep into games, but his current form is a clear upgrade over the typical pitching Cincinnati faces.
⭐ Editor’s Prediction
Recent head-to-head clashes between these sides have shown just how quickly a game can turn into a slugfest. Still, the market has set the line at 10.5, factoring in both the hitter-friendly ballpark and the offensive firepower on display. However, tonight’s starting pitchers-Burnes and Holmes-both sport ERAs under 2.90, and neither needs to go seven scoreless innings; their job is simply to avoid an early blow-up. The Reds’ shaky bullpen remains the biggest concern, especially against the Cubs’ deep lineup. Even so, a 6-4 scoreline would keep this bet safe, and it would take at least 11 runs to lose. Our pick is the under 10.5 total runs.