Dodgers vs Cardinals Prediction 4 September 2026
📡 St. Louis have already given the Dodgers a tough night in this series, racking up 13 runs in the opener. That blow is especially striking given Los Angeles' recent form, where wins have been mixed with surprising setbacks. Tonight, the hosts send Tarik Skubal to the mound-the kind of September matchup the Dodgers bolstered their rotation for during the summer. St. Louis counters with young Quinn Mathews, who will be making his first start against this Dodgers lineup.
Head-to-Head
📊 St. Louis have come out on top in seven of their last ten head-to-head clashes. The Cardinals took two of three meetings in May and opened the current series with a 13-8 victory. Six of those last ten games went under the total, although the most recent matchup bucked that trend completely. The Dodgers have struggled against this opponent for quite some time, so their seasonal records alone aren’t enough to justify backing the spread here.
Head-to-head statistics Dodgers - Cardinals

Los Angeles Dodgers Team Overview
The Dodgers currently top the National League West and have won roughly 60% of their home games. August has been a bit uneven for them, but their roster depth remains elite: Mookie Betts, Freddie Freeman, Kyle Tucker, and the rest of the core are more than capable of capitalizing on any lapse in control from opposing pitchers. With Will Smith back in the lineup, Los Angeles look even deeper. When it comes to covering the spread, it’s especially significant that the Dodgers can put constant pressure on a young lefty without a real weak spot anywhere in their batting order.
Match Results: Los Angeles Dodgers

St. Louis Cardinals Team Overview
The Cardinals have moved back into the wild card race after an impressive 13-8 victory. The injection of young talent has energized the roster-Thomas Saggese has delivered a significant power boost, while Leo Bernal made an immediate impact following his MLB call-up. Still, the previous weeks were challenging, with just three wins in ten games before heading to Los Angeles. Pitching remains the team’s most inconsistent area.
Match Results: St. Louis Cardinals
⚾ Starting Pitchers
Tarik Skubal enters the game with an 8-7 record and a 2.84 ERA. Over his last five starts, he’s posted a 3.00 ERA, and in his previous outing against Detroit, he worked six innings, allowing just one earned run with seven strikeouts and no walks. Across his last three starts, Skubal has racked up 25 strikeouts in 19 innings. For the Dodgers, this is exactly the kind of starting pitching edge that makes a run line play attractive.
Quinn Mathews is 1-2 with a 5.03 ERA through his first MLB starts. His most recent appearance was solid-one run allowed over 5.2 innings against Pittsburgh, striking out seven. However, Philadelphia tagged him for seven earned runs in just five innings the outing before. The young lefty has already shown flashes of high potential, but tonight he faces by far the deepest lineup he’s seen so far.
⭐ Editor's Pick
St. Louis have earned some caution after racking up 13 runs in Los Angeles, and Matthews heads into this matchup on the back of a strong start. Skubal gives the Dodgers a completely different look at the top of the rotation-he rarely allows extra traffic via walks and has returned to elite strikeout numbers over his last three outings. The hosts feature several right-handed bats who can put pressure on Matthews the second time through the order. The moneyline on a straightforward Dodgers win is too short, so we’re taking on a bit more risk for a better return. Our pick: Los Angeles Dodgers -1.5.