Cubs vs Diamondbacks Prediction 2 May 2026
📡 Chicago have already claimed the first game of the series (6-5), holding off a late surge from Arizona and extending their home winning streak to nine games. Reuters highlights that the Cubs have won 13 of their last 16 games, and on May 2, they host Shota Imanaga against Ryne Nelson. Given these circumstances, betting on a home victory seems the most logical choice: form, home field advantage, and the starting matchup all favor Chicago.
Head-to-Head
📊 In the last 10 head-to-head encounters, Chicago holds a 6-4 advantage. There isn't a clear trend in terms of totals: there have been four overs, four unders, and two pushes, so the historical matchups don't particularly suggest betting on the total. What's more crucial for the outcome is that the Cubs recently clinched a win (6-5), with some of their previous victories also coming through home-field dominance and timely offense.
Head-to-head statistics Cubs - Diamondbacks

Chicago Cubs Team Overview
The Cubs currently hold a 20-12 record, with a 12-5 mark at home, and they appear to be one of the most consistent teams during this stretch. In the opening game of the series, the hosts secured their victory through two three-run innings, with Michael Busch delivering crucial RBIs early in the match. There's a concern regarding Nico Hoerner's neck, but Chicago's roster is deep enough not to rely on a single player. The key takeaway is that the team wins at home even in games where the opposition stages a late rally.
Match Results: Chicago Cubs

Arizona Diamondbacks Team Overview
Arizona remain a threat at the plate and nearly staged a comeback in the first game of the series after trailing 1-6. Ildemaro Vargas collected four hits, extending his hitting streak to 24 games, while Geraldo Perdomo launched a three-run homer. However, the visitors have a different issue: their starting pitching once again allowed the opponent too many early opportunities, and such a scenario will be tougher to overcome against Imanaga. On the road, Arizona need to start cleaner than they did on Friday.
Match Results: Arizona Diamondbacks
⚾ Starting Pitchers
Chicago will start Shota Imanaga. ESPN lists him as the probable starter against Nelson, while FanDuel records him at 2-2 for the season. After the Cubs took the first game of the series, Imanaga is expected to provide a steadier start for the hosts and prevent Arizona from mounting an early comeback scenario.
For Arizona, Ryne Nelson takes the mound. ESPN has him at 1-2 with a 7.71 ERA, and Fox Sports confirms the same starter line ahead of the game at Wrigley Field. This poses a significant risk for the visitors: facing a hot Cubs offense at home, such a profile could result in early runs within the first innings. If Nelson allows traffic on the bases again, Arizona will find themselves playing catch-up throughout the game.
⭐ Editorial Prediction
Chicago currently hold the upper hand in all key aspects: form, home advantage, initial match-up, and recent series results. Arizona have shown they can stay competitive through their offense, as demonstrated in Friday's 6-5 game. However, it will be much tougher to recover from an early setback against a stronger starter for a second consecutive day. The Cubs have won nine straight at home and face an opponent whose starter has an ERA over seven. Even if the game turns out to be tense again, the more reliable path to victory remains with the hosts. It makes sense to back a Chicago Cubs win.
