Astros vs Diamondbacks Prediction 5 September 2026

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The main thing

    📡 Houston opened their homestand with a 3-1 win, once again capitalizing on their pitching. In seven of their last nine games, Astros’ opponents have been held to three runs or fewer, while Arizona arrived in Texas with their offense struggling. In the series opener, the Diamondbacks managed just three hits and, for the fourth straight game, scored only a single run.

    Head-to-Head

    📊 Houston have claimed victory in eight of their last ten head-to-head matchups. This fixture often sees the Astros control the tempo through dominant pitching; heading into this series, Houston have won eight of their previous nine games against Arizona.

    Head-to-head statistics Astros - Diamondbacks

    55%
    29 Wins
    40%
    21 Wins
    05.09.26
    major league baseball
    Houston Astros
    Houston Astros
    Arizona Diamondbacks
    Arizona Diamondbacks
    3
    1
    0
    0
    0
    0
    3
    0
    0
    1
    0
    0
    0
    0
    0
    0
    0
    0
    23.07.25
    MLB
    Arizona Diamondbacks
    Arizona Diamondbacks
    Houston Astros
    Houston Astros
    3
    4
    1
    0
    0
    0
    0
    0
    0
    0
    0
    0
    0
    2
    0
    0
    2
    1
    0
    1
    23.07.25
    MLB
    Arizona Diamondbacks
    Arizona Diamondbacks
    Houston Astros
    Houston Astros
    1
    3
    0
    0
    0
    0
    0
    0
    0
    0
    1
    0
    0
    0
    0
    0
    0
    2
    0
    1
    22.07.25
    MLB
    Arizona Diamondbacks
    Arizona Diamondbacks
    Houston Astros
    Houston Astros
    3
    6
    1
    0
    0
    3
    1
    1
    0
    0
    1
    0
    0
    0
    0
    2
    0
    0
    0
    0
    08.09.24
    MLB
    Houston Astros
    Houston Astros
    Arizona Diamondbacks
    Arizona Diamondbacks
    6
    12
    0
    0
    0
    3
    0
    5
    2
    0
    3
    1
    0
    0
    0
    1
    0
    1
    1
    1
    Empty
    There are no events
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    Houston Astros Team Overview

    The Astros had won seven out of their last ten games heading into the series against Arizona, and then added another victory to their tally. Their pitching, especially at home, has been particularly impressive: heading into Friday’s game, Houston’s starting pitchers held a 1.66 ERA over a four-game home stretch. In the series opener against the Diamondbacks, the relievers combined to shut out Arizona over four innings.

    Match Results: Houston Astros

    05.09.26
    major league baseball
    Houston Astros
    Houston Astros
    Arizona Diamondbacks
    Arizona Diamondbacks
    3
    1
    0
    0
    0
    0
    3
    0
    0
    1
    0
    0
    0
    0
    0
    0
    0
    0
    W
    03.09.26
    major league baseball
    Houston Astros
    Houston Astros
    Chicago White Sox
    Chicago White Sox
    6
    2
    2
    0
    0
    2
    4
    0
    0
    0
    0
    0
    0
    0
    0
    0
    0
    0
    W
    03.09.26
    major league baseball
    Houston Astros
    Houston Astros
    Chicago White Sox
    Chicago White Sox
    2
    0
    0
    0
    0
    0
    0
    0
    0
    0
    0
    0
    0
    0
    0
    0
    2
    0
    W
    02.09.26
    major league baseball
    Houston Astros
    Houston Astros
    Chicago White Sox
    Chicago White Sox
    1
    5
    0
    0
    0
    0
    0
    0
    0
    0
    0
    3
    0
    0
    0
    2
    1
    0
    0
    0
    L
    01.09.26
    major league baseball
    Houston Astros
    Houston Astros
    Chicago White Sox
    Chicago White Sox
    6
    3
    0
    0
    0
    0
    1
    0
    2
    2
    3
    0
    0
    0
    0
    1
    0
    0
    W
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    Arizona Diamondbacks Team Overview

    Arizona’s main concern right now is in the batter’s box. They dropped the series opener 1-3, failed to record a single hit with runners in scoring position, and have managed just one run for the fourth straight game. Even when they get runners on base, they can’t string together the kind of big, productive innings they need.

    Match Results: Arizona Diamondbacks

    05.09.26
    major league baseball
    Houston Astros
    Houston Astros
    Arizona Diamondbacks
    Arizona Diamondbacks
    3
    1
    0
    0
    0
    0
    3
    0
    0
    1
    0
    0
    0
    0
    0
    0
    0
    0
    L
    02.09.26
    major league baseball
    Arizona Diamondbacks
    Arizona Diamondbacks
    Philadelphia Phillies
    Philadelphia Phillies
    1
    0
    0
    0
    0
    0
    0
    0
    0
    0
    0
    0
    0
    0
    0
    0
    1
    0
    W
    02.09.26
    major league baseball
    Arizona Diamondbacks
    Arizona Diamondbacks
    Philadelphia Phillies
    Philadelphia Phillies
    1
    7
    0
    2
    0
    0
    0
    0
    0
    0
    1
    1
    0
    0
    0
    0
    0
    3
    0
    1
    L
    01.09.26
    major league baseball
    Arizona Diamondbacks
    Arizona Diamondbacks
    Philadelphia Phillies
    Philadelphia Phillies
    1
    2
    0
    0
    0
    1
    1
    1
    0
    0
    0
    0
    0
    0
    0
    0
    0
    0
    0
    0
    L
    30.08.26
    major league baseball
    San Francisco Giants
    San Francisco Giants
    Arizona Diamondbacks
    Arizona Diamondbacks
    7
    2
    1
    0
    0
    0
    0
    1
    0
    0
    3
    0
    0
    0
    1
    1
    2
    0
    L
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    ⚾ Starting Pitchers

    Houston are sending Ethan Pecko to the mound. His MLB sample size remains limited-just 13 innings pitched, with a 6.23 ERA and a 1.54 WHIP. The nine walks he's issued in that span highlight the main concern for the Astros: they simply can't afford to give Arizona free passes tonight.

    Brandon Pfaadt enters the matchup with a 7-2 record, a 3.49 ERA, and a 1.14 WHIP. He does a solid job of limiting baserunners, having allowed only 27 walks over 111 innings. This gives Arizona a strong chance to keep the Astros' offense in check.

    ⭐ Editor’s Prediction

    The 9.5-run line offers a solid cushion for a matchup where one offense has all but stalled. Arizona have been held to a single run in four straight games, while Houston picked up Friday’s win without any major offensive fireworks. Pfaadt is capable of delivering five or six quality innings for the visitors, and the Astros’ bullpen just locked down the late frames in the series opener. The main risk lies with Pfaadt’s control-extra walks could give Arizona some much-needed chances. Still, given the Diamondbacks’ current struggles at the plate and Houston’s strong pitching, another relatively low-scoring contest looks likely. We’re backing the under 9.5 total runs.

    Total Under (9,5)
    Published: 05/09/2026, 06:42
    Evgeny Lisin
    Evgeny Lisin
    Baseball expert
    48
    1
    57
    106 predictions
    Statistics for September 2026

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    Betting Tips: Houston Astros - Arizona Diamondbacks

    Houston Astros have won:
    houston-astrosarizona-diamondbacksin 9 of last 10 games against Arizona Diamondbacks (MLB).
    Houston Astros Win
    Bovada
    -110
    Under 9.5 runs scored:
    houston-astrosin last 9 Houston Astros games (MLB).
    houston-astrosin last 5 Houston Astros home games (MLB).
    arizona-diamondbacksin 11 of last 12 Arizona Diamondbacks games (MLB).
    Total Under (9,5)
    -179
    Arizona Diamondbacks have scored under 4.5 runs:
    arizona-diamondbacksin last 5 games (MLB).
    Arizona Diamondbacks Total Under (4,5)
    -137
    Houston Astros won with a +1.5 handicap:
    houston-astrosarizona-diamondbacksin 9 of last 10 games against Arizona Diamondbacks (MLB).
    houston-astrosin 7 of last 8 home games (MLB).
    Houston Astros Handicap (+1,5)
    Bovada
    -169