Serie A Matchday 4 Preview, September 11-14

It feels as though the new Serie A season has only just begun, yet Matchday 4 is already taking place this week. Most of the top clubs, with the exception of Napoli, are still setting a very high standard. At the other end of the table, three teams have failed to collect a single point from their opening three matches. There is therefore plenty of intrigue ahead of the next round, with something worth following in every fixture.
Venezia vs Fiorentina
Matchday 4 opens with two teams that have made a frankly disastrous start to the season. After three matches, Venezia and Fiorentina are both still without a point and sit in the relegation zone. Following another defeat, the Viola even decided to change head coach, clearly determined to avoid a repeat of last season's scenario. In the upcoming meeting, at least one of the two sides will finally be able to end a prolonged run without a point.
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Genoa vs Frosinone
Genoa are the third Serie A team still without a point after three rounds. The Grifoni have, however, been genuinely unlucky with the schedule: they opened the campaign against Napoli (0-2), Lazio (0-1) and Como (1-4), so the losing run is understandable. A home match against Frosinone, who have only just been promoted from Serie B, looks like an excellent opportunity to finally add to their points tally. The visitors should not be underestimated, though: they have already won two of their opening three matches.
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Lazio vs Milan
One of the main matches of the round takes place in Rome, where Lazio host Milan. After a disappointing previous season, the Eagles have started the new Serie A campaign brightly with three wins from three. The Rossoneri also look confident under their new coaching staff, collecting seven points from a possible nine, with their only setback coming in a 1-1 away draw with Juventus. After such strong starts, both teams will be keen to maintain their momentum, making this one of the most interesting fixtures of the week.
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Atalanta vs Cagliari
Both teams have six points after three rounds. Each has already slipped up against stronger opposition: Cagliari narrowly lost 0-1 at home to Inter in Matchday 2, while Atalanta were beaten 1-2 away by Roma last weekend, with the capital club in excellent form at the start of the season. The Bergamo side were actually very close to victory and led until the 89th minute before completely collapsing at the end. At home, Atalanta will certainly look to respond, but the task will not be easy: Cagliari have been extremely reliable defensively and have conceded only once in three matches.
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Lecce vs Monza
Lecce against Monza is unlikely to attract the biggest television audience of the weekend, but that does not make the fixture any less important. Both teams are highly likely to spend much of the season battling relegation, so collecting points against potential direct rivals is especially valuable. Neither has started particularly well: Lecce have three points, earned through a 2-0 win over fellow Serie A newcomers Venezia, while Monza have managed just one. This meeting gives both sides a good opportunity to improve their position in the table.
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Napoli vs Bologna
Italy's runners-up have been thoroughly unconvincing at the start of the season, taking only three points from a possible nine and sitting 12th. Napoli also produced a very poor home performance against Arsenal in the Champions League a few days ago, where they were fortunate to avoid a heavier defeat in a 0-1 loss. Bologna, regarded as a solid Serie A mid-table side capable of challenging for European places, have also struggled to find their game and have collected only one point. That gives this fixture added significance for both teams: another dropped result could already begin to look like a warning sign.
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Sassuolo vs Juventus
Juventus have produced mixed impressions with their performances at the start of the season. On the one hand, they have taken seven points from a possible nine; on the other, the results have hardly been convincing. The Old Lady laboured to wins over Frosinone (1-0) and Parma (2-0), while in the previous round they needed a goal in the 90+2nd minute to avoid a home defeat against Milan (1-1). A trip to Sassuolo does not promise an easy ride either: the hosts continue to set a high standard this season, so Juventus will have to work hard for all three points.
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Como vs Parma
Como, the biggest revelation of last season, have not slowed down and have entered the new Serie A campaign with confidence. They dropped points against Udinese in Matchday 1 (1-1), but then beat Napoli 2-1 away and thrashed Genoa 4-1. Parma have had the opposite start: just one point, earned in a 1-1 home draw with Monza, leaves them 16th. There is also an extra workload factor for the hosts, who are due to face RB Leipzig in the Champions League a few days before this match, something that could affect both preparation and team selection.
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Torino vs Roma
One of the most intriguing fixtures of Matchday 4 takes place in Turin, where Torino host Roma. The main question is just how sustainable the Giallorossi's early-season results really are. Roma have collected nine points from nine and lead the table, helped in no small part by two emphatic victories. Torino, however, are a solid Serie A mid-table side who rarely make life easy for opponents. The trip to Turin could therefore prove an even more serious test for Roma than their recent 2-1 meeting with Atalanta.
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Inter vs Udinese
Inter and Udinese close the Matchday 4 programme. As befits the reigning Italian champions, the Nerazzurri have opened the season with three consecutive wins and remain perfect in Serie A. The only slight blemish was a 1-2 Champions League defeat to Real Madrid, although on the balance of play Inter fully deserved at least a draw. They will certainly look to respond in front of their own supporters. Udinese should not be underestimated, however: the visitors have also made a solid start to the season and are unlikely to give up points without a fight.
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Matchday 4 Summary
Although Matchday 4 does not feature quite as many blockbuster fixtures as the previous week, there are still plenty of interesting matches for both watching and betting. Can Lazio, who remain perfect, beat Milan? Roma are equally worth following after making the strongest start in the league and moving to the top of the table. Venezia against Fiorentina also deserves special attention: both teams are near the bottom, concede plenty of goals and desperately need their first points. There should be no shortage of entertainment this round. Those looking for a bonus can check the list at https://scores24.live/en/sportbooks-it
FAQ
When will Serie A Matchday 4 in 2026/2027 take place?
Serie A Matchday 4 will be played from September 11 to 14, 2026.
Which match is the headline fixture of Serie A Matchday 4 in the 2026/27 season?
The headline game of Matchday 4 will be Lazio vs Milan. Both teams have started the season strongly, are collecting points consistently and sit among the league leaders. Their head-to-head meeting is therefore one of the most attractive fixtures of the week.


