Niners vs Arizona Cardinals Prediction 21 September 2025

    San Francisco 49ers
    San Francisco 49ers
    Arizona Cardinals
    Arizona Cardinals
    16
    15
    0
    6
    0
    10
    0
    3
    3
    9

    🔊How will the teams use their running backs to gain a lot of yards? In the upcoming match of the "NFL" tournament, the teams San Francisco 49ers and Arizona Cardinals will face off, with bookmakers setting the odds as follows: and , respectively. The game is scheduled to start on 21 September at 20:25, and will take place at the “Levi's Stadium” stadium in the city of Santa Clara. According to forecasts, the advantage in the upcoming match will be on the side of the San Francisco 49ers team.

    Head-to-Head

    Before you is a detailed analysis of the history of H2H between the sides. In total, the home team San Francisco 49ers has 19 wins (10 at home). The team Arizona Cardinals has won 17 wins times, with 8 of those wins coming away. It is worth noting that the average number of points scored by the hosts is 23.28. The guests, on the other hand, score an average of 20.61 point per game.

    Head-to-head statistics Niners - Arizona Cardinals

    56%
    22 Wins
    0%
    0 Draws
    44%
    17 Wins
    27.09.26
    НФЛ
    San Francisco 49ers
    San Francisco 49ers
    Arizona Cardinals
    Arizona Cardinals
    36
    30
    7
    0
    10
    6
    6
    7
    13
    17
    16.11.25
    НФЛ
    Arizona Cardinals
    Arizona Cardinals
    San Francisco 49ers
    San Francisco 49ers
    22
    41
    7
    13
    3
    12
    0
    10
    12
    6
    21.09.25
    НФЛ
    San Francisco 49ers
    San Francisco 49ers
    Arizona Cardinals
    Arizona Cardinals
    16
    15
    0
    0
    6
    3
    0
    3
    10
    9
    05.01.25
    НФЛ
    Arizona Cardinals
    Arizona Cardinals
    San Francisco 49ers
    San Francisco 49ers
    47
    24
    3
    3
    17
    14
    6
    7
    21
    0
    06.10.24
    НФЛ
    San Francisco 49ers
    San Francisco 49ers
    Arizona Cardinals
    Arizona Cardinals
    23
    24
    10
    7
    13
    3
    0
    3
    0
    11
    Empty
    There are no events
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    San Francisco 49ers Team Overview

    What can the current home team boast of? The team San Francisco 49ers has played 2 matches this season, winning 2 (100%) and losing 0 (0%). The average total points scored by players is 21.5, while the average total points conceded is 17. In home games, these figures are 0 and 0, respectively. The overall average total points per match is 38.5.

    If we consider only the last 10 official matches, the team has 3 wins (1 of them at home) and 7 losses (at home - 3).

    In this 10-match period, the average total points scored per game is 46.7. The average points scored by San Francisco 49ers are 19.9 (at home - 23.75), while the average points conceded are 26.8 (in home games - 21.25).

    Match Results: San Francisco 49ers

    27.09.26
    НФЛ
    San Francisco 49ers
    San Francisco 49ers
    Arizona Cardinals
    Arizona Cardinals
    36
    30
    7
    0
    10
    6
    6
    7
    13
    17
    W
    20.09.26
    НФЛ
    San Francisco 49ers
    San Francisco 49ers
    Miami Dolphins
    Miami Dolphins
    35
    13
    7
    0
    7
    6
    21
    0
    0
    7
    W
    11.09.26
    НФЛ
    Los Angeles Rams
    Los Angeles Rams
    San Francisco 49ers
    San Francisco 49ers
    7
    27
    0
    3
    7
    7
    0
    7
    0
    10
    W
    28.08.26
    NFL Preseason
    Las Vegas Raiders
    Las Vegas Raiders
    San Francisco 49ers
    San Francisco 49ers
    12
    18
    6
    0
    3
    6
    0
    3
    3
    9
    W
    21.08.26
    NFL Preseason
    Los Angeles Chargers
    Los Angeles Chargers
    San Francisco 49ers
    San Francisco 49ers
    17
    41
    0
    0
    3
    20
    6
    7
    8
    14
    W
    Empty
    There are no events
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    Arizona Cardinals Team Overview

    This season, the team Arizona Cardinals has already played 2 and is now ready to test its strength on the road. The team approaches the upcoming match with 2 wins and 0 losses. The win percentage is 100%, while the loss percentage is 0%. The average points scored per match is 23.5, and the average points conceded is 17.5. In away games, these figures are 20 and 13, respectively. When it comes to the total points per match, the average is 41.

    Analyzing the team Arizona Cardinals, we should also consider the results of the last 10 official matches, which ended with 5 wins (1 of them away) and 5 losses (4 of them away).

    The average statistics for the last 10 games are as follows:

    • average points scored: 24 (away: 17.4);
    • average points conceded: 20 (away: 20.2);
    • average total points per match: 44.

    Match Results: Arizona Cardinals

    27.09.26
    НФЛ
    San Francisco 49ers
    San Francisco 49ers
    Arizona Cardinals
    Arizona Cardinals
    36
    30
    7
    0
    10
    6
    6
    7
    13
    17
    L
    20.09.26
    НФЛ
    Arizona Cardinals
    Arizona Cardinals
    Seattle Seahawks
    Seattle Seahawks
    7
    31
    0
    7
    7
    0
    0
    10
    0
    14
    L
    13.09.26
    НФЛ
    Los Angeles Chargers
    Los Angeles Chargers
    Arizona Cardinals
    Arizona Cardinals
    14
    26
    7
    7
    0
    6
    7
    3
    0
    10
    W
    29.08.26
    NFL Preseason
    Green Bay Packers
    Green Bay Packers
    Arizona Cardinals
    Arizona Cardinals
    42
    38
    3
    3
    21
    17
    0
    11
    18
    7
    L
    23.08.26
    NFL Preseason
    Arizona Cardinals
    Arizona Cardinals
    Dallas Cowboys
    Dallas Cowboys
    13
    34
    0
    14
    6
    10
    7
    3
    0
    7
    L
    Empty
    There are no events
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    Editorial Prediction

    ✅ To conclude our preview of San Francisco 49ers vs Arizona Cardinals, let’s highlight the most promising betting option. The game may unfold in various directions - typical for the american football - but that’s exactly why a careful approach is required. Taking all factors into account, the most logical pick appears to be:

    Total points Over (43,5)
    Odds-137
    Published: 21/09/2025, 08:42

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    Niners - Arizona Cardinals Table position

    NFL 25/26
    gWLPDForm
    7.
    Los Angeles Rams
    Los Angeles Rams
    17125518-346
    8.
    San Francisco 49ers
    San Francisco 49ers
    17125437-371
    9.
    Chicago Bears
    Chicago Bears
    17116441-415
    28.
    New York Giants
    New York Giants
    17413381-439
    29.
    Arizona Cardinals
    Arizona Cardinals
    17314355-488
    30.
    Las Vegas Raiders
    Las Vegas Raiders
    17314241-432