Niners vs Arizona Cardinals Prediction 21 September 2025
🔊How will the teams use their running backs to gain a lot of yards? In the upcoming match of the "NFL" tournament, the teams San Francisco 49ers and Arizona Cardinals will face off, with bookmakers setting the odds as follows: and , respectively. The game is scheduled to start on 21 September at 20:25, and will take place at the “Levi's Stadium” stadium in the city of Santa Clara. According to forecasts, the advantage in the upcoming match will be on the side of the San Francisco 49ers team.
Head-to-Head
Head-to-head statistics Niners - Arizona Cardinals

San Francisco 49ers Team Overview
What can the current home team boast of? The team San Francisco 49ers has played 2 matches this season, winning 2 (100%) and losing 0 (0%). The average total points scored by players is 21.5, while the average total points conceded is 17. In home games, these figures are 0 and 0, respectively. The overall average total points per match is 38.5.
If we consider only the last 10 official matches, the team has 3 wins (1 of them at home) and 7 losses (at home - 3).
In this 10-match period, the average total points scored per game is 46.7. The average points scored by San Francisco 49ers are 19.9 (at home - 23.75), while the average points conceded are 26.8 (in home games - 21.25).
Match Results: San Francisco 49ers

Arizona Cardinals Team Overview
This season, the team Arizona Cardinals has already played 2 and is now ready to test its strength on the road. The team approaches the upcoming match with 2 wins and 0 losses. The win percentage is 100%, while the loss percentage is 0%. The average points scored per match is 23.5, and the average points conceded is 17.5. In away games, these figures are 20 and 13, respectively. When it comes to the total points per match, the average is 41.
Analyzing the team Arizona Cardinals, we should also consider the results of the last 10 official matches, which ended with 5 wins (1 of them away) and 5 losses (4 of them away).
The average statistics for the last 10 games are as follows:
- average points scored: 24 (away: 17.4);
- average points conceded: 20 (away: 20.2);
- average total points per match: 44.
Match Results: Arizona Cardinals
Editorial Prediction
✅ To conclude our preview of San Francisco 49ers vs Arizona Cardinals, let’s highlight the most promising betting option. The game may unfold in various directions - typical for the american football - but that’s exactly why a careful approach is required. Taking all factors into account, the most logical pick appears to be: